| 1. Jornada | 08.01.2022 | Gallos Blancos [] | - | CF América [] | 0:4 | ||||
| 2. Jornada | 26.01.2022 | CF América [] | - | Pumas UNAM [] | 1:2 | ||||
| 4. Jornada | 29.01.2022 | CF Pachuca [] | - | CF América [] | 3:0 | ||||
| 11. Jornada | 19.03.2022 | Pumas UNAM [] | - | CF América [] | 1:1 | ||||
| 13. Jornada | 03.04.2022 | Club Necaxa [] | - | CF América [] | 1:2 | ||||
| 16. Jornada | 24.04.2022 | CF América [] | - | CF Pachuca [] | 4:3 |  |
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| 14. Jornada | 27.04.2022 | CF América [] | - | Cruz Azul [] | 6:1 | |
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| 17. Jornada | 30.04.2022 | Puebla FC [] | - | CF América [] | 2:3 |  |
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| 18. Jornada | 07.05.2022 | CF América [] | - | FC Juárez [] | 3:0 | |
México