| 1. Jornada | 02.06.2021 | Albion | - | CA Cerro | 1:2 | ||||
| 2. Jornada | 11.06.2021 | CA Cerro | - | Defensor Sporting | 0:0 |  |
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| 4. Jornada | 25.06.2021 | CA Cerro | - | Atenas | 1:1 | ||||
| 9. Jornada | 31.07.2021 | Rampla Juniors | - | CA Cerro | 0:1 | ||||
| 10. Jornada | 06.08.2021 | CA Cerro | - | Danubio | 1:1 | ||||
| 11. Jornada | 12.08.2021 | Rocha | - | CA Cerro | 1:3 |  |
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| 13. Jornada | 23.09.2021 | Defensor Sporting | - | CA Cerro | 2:0 | ||||
| 16. Jornada | 14.10.2021 | CA Cerro | - | Racing | 1:0 | ||||
| 17. Jornada | 20.10.2021 | Villa Teresa | - | CA Cerro | 1:2 | ||||
| 18. Jornada | 29.10.2021 | CA Cerro | - | Juventud de Las Piedras | 2:1 | ||||
| 19. Jornada | 03.11.2021 | Uruguay Montevideo | - | CA Cerro | 1:2 | ||||
| 21. Jornada | 18.11.2021 | Danubio | - | CA Cerro | 0:0 |
Uruguay