| 1. Jornada | 12.09.2021 | Olympiacos | - | Atromitos | 0:0 | ||||
| 2. Jornada | 19.09.2021 | Lamia | - | Olympiacos | 1:2 |  |
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| 3. Jornada | 22.09.2021 | Olympiacos | - | Apollon Smyrnis | 4:1 | ||||
| 4. Jornada | 26.09.2021 | Asteras Tripolis | - | Olympiacos | 0:2 |  |
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| 5. Jornada | 03.10.2021 | Olympiacos | - | Panathinaikos | 0:0 | |
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| 6. Jornada | 17.10.2021 | PAS Giannina | - | Olympiacos | 1:2 | ||||
| 7. Jornada | 24.10.2021 | Olympiacos | - | PAOK Saloniki | 2:1 | ||||
| 8. Jornada | 30.10.2021 | Panetolikos | - | Olympiacos | 1:2 | ||||
| 9. Jornada | 07.11.2021 | Olympiacos | - | Ionikos Nikea | 1:0 | ||||
| 10. Jornada | 21.11.2021 | AEK Athen | - | Olympiacos | 2:3 | ||||
| 11. Jornada | 28.11.2021 | Olympiacos | - | Volos NFC | 2:1 | ||||
| 12. Jornada | 04.12.2021 | OFI Heraklion | - | Olympiacos | 1:3 | |
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| 13. Jornada | 12.12.2021 | Olympiacos | - | Aris Saloniki | 1:0 | |
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| 14. Jornada | 15.12.2021 | Atromitos | - | Olympiacos | 0:3 | ||||
| 15. Jornada | 19.12.2021 | Olympiacos | - | Lamia | 1:0 | ||||
| 24. Jornada | 20.02.2022 | Volos NFC | - | Olympiacos | 0:1 | ||||
| 25. Jornada | 27.02.2022 | Olympiacos | - | OFI Heraklion | 2:0 | ||||
| 17. Jornada | 02.03.2022 | Olympiacos | - | Asteras Tripolis | 5:1 | ||||
| 26. Jornada | 06.03.2022 | Aris Saloniki | - | Olympiacos | 2:1 |
Senegal