| 2. Jornada | 12.09.2021 | AEK Larnaca | - | Omonia Nikosia | 2:1 | ||||
| 3. Jornada | 20.09.2021 | Omonia Nikosia | - | Doxa Katokopias | 2:1 | ||||
| 5. Jornada | 03.10.2021 | Olympiacos Nikosia | - | Omonia Nikosia | 1:0 | ||||
| 7. Jornada | 25.10.2021 | PAEEK | - | Omonia Nikosia | 1:0 |  |
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| 8. Jornada | 29.10.2021 | Omonia Nikosia | - | Anorthosis Famagusta | 0:1 | ||||
| 11. Jornada | 26.12.2021 | APOEL Nikosia | - | Omonia Nikosia | 4:2 | ||||
| 16. Jornada | 10.01.2022 | Omonia Nikosia | - | Olympiacos Nikosia | 1:0 | ||||
| 17. Jornada | 16.01.2022 | Apollon Limassol | - | Omonia Nikosia | 2:0 | ||||
| 18. Jornada | 24.01.2022 | Omonia Nikosia | - | PAEEK | 2:1 | ||||
| 19. Jornada | 29.01.2022 | Anorthosis Famagusta | - | Omonia Nikosia | 1:1 |
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