| 3. Jornada | 01.03.2022 | Santa Cruz | - | CD Magallanes | 1:2 |  |
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| 4. Jornada | 07.03.2022 | Fernández Vial | - | Santa Cruz | 1:0 | ||||
| 6. Jornada | 24.03.2022 | Santa Cruz | - | Barnechea | 1:1 | ||||
| 16. Jornada | 22.05.2022 | Deportes Melipilla | - | Santa Cruz | 1:0 | ||||
| 17. Jornada | 28.05.2022 | Santa Cruz | - | Santiago Wanderers | 2:0 |  |
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| 5. Jornada | 02.06.2022 | Cobreloa | - | Santa Cruz | 1:0 |  |
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| 18. Jornada | 02.07.2022 | Deportes Temuco | - | Santa Cruz | 1:1 | ||||
| 19. Jornada | 09.07.2022 | Santa Cruz | - | Santiago Morning | 1:0 | ||||
| 20. Jornada | 16.07.2022 | CD Magallanes | - | Santa Cruz | 0:0 | |
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| 21. Jornada | 27.07.2022 | Santa Cruz | - | Fernández Vial | 2:0 | ||||
| 22. Jornada | 01.08.2022 | Santa Cruz | - | Cobreloa | 1:1 | |
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| 23. Jornada | 08.08.2022 | Barnechea | - | Santa Cruz | 2:0 | ||||
| 29. Jornada | 26.09.2022 | Santa Cruz | - | Puerto Montt | 0:2 | ||||
| 31. Jornada | 11.10.2022 | Santa Cruz | - | Unión San Felipe | 4:0 | ||||
| 32. Jornada | 16.10.2022 | San Luis | - | Santa Cruz | 0:0 | ||||
| 33. Jornada | 24.10.2022 | Santa Cruz | - | Deportes Melipilla | 2:1 |
Chile