| 1. Jornada | 24.07.2021 | CF Monterrey [Sub 18] | - | Puebla FC [Sub 18] | 0:0 | ||||
| 2. Jornada | 30.07.2021 | Puebla FC [Sub 18] | - | Deportivo Guadalajara [Sub 18] | 1:3 | ||||
| 3. Jornada | 07.08.2021 | CF América [Sub 18] | - | Puebla FC [Sub 18] | 1:0 | ||||
| 4. Jornada | 13.08.2021 | Puebla FC [Sub 18] | - | UANL Tigres [Sub 18] | 1:2 | ||||
| 5. Jornada | 17.08.2021 | Club Tijuana [Sub 18] | - | Puebla FC [Sub 18] | 5:2 | ||||
| 6. Jornada | 22.08.2021 | Pumas UNAM [Sub 18] | - | Puebla FC [Sub 18] | 3:3 | ||||
| 8. Jornada | 10.09.2021 | Puebla FC [Sub 18] | - | Atlético San Luis [Sub 18] | 1:3 | ||||
| 13. Jornada | 15.10.2021 | Club Necaxa [Sub 18] | - | Puebla FC [Sub 18] | 4:3 | ||||
| 14. Jornada | 19.10.2021 | Puebla FC [Sub 18] | - | Mazatlán FC [Sub 18] | 0:2 | ||||
| 15. Jornada | 23.10.2021 | Puebla FC [Sub 18] | - | Club León [Sub 18] | 2:1 | ||||
| 16. Jornada | 29.10.2021 | FC Juárez [Sub 18] | - | Puebla FC [Sub 18] | 0:2 | ||||
| 17. Jornada | 05.11.2021 | Puebla FC [Sub 18] | - | Deportivo Toluca [Sub 18] | 3:1 |  |
México