| 2. Jornada | 12.09.2021 | Doxa Katokopias | - | Anorthosis Famagusta | 2:0 | ||||
| 3. Jornada | 20.09.2021 | Anorthosis Famagusta | - | Ethnikos Achna | 2:1 | ||||
| 4. Jornada | 25.09.2021 | Aris Limassol | - | Anorthosis Famagusta | 3:2 | ||||
| 5. Jornada | 03.10.2021 | Anorthosis Famagusta | - | APOEL Nikosia | 2:1 | ||||
| 7. Jornada | 25.10.2021 | Anorthosis Famagusta | - | AEK Larnaca | 1:2 |  |
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| 9. Jornada | 07.11.2021 | Anorthosis Famagusta | - | Paphos FC | 1:0 | ||||
| 13. Jornada | 13.12.2021 | Anorthosis Famagusta | - | Doxa Katokopias | 2:0 | ||||
| 14. Jornada | 18.12.2021 | Ethnikos Achna | - | Anorthosis Famagusta | 0:2 | ||||
| 17. Jornada | 16.01.2022 | Anorthosis Famagusta | - | AEL Limassol | 2:1 | ||||
| 18. Jornada | 24.01.2022 | AEK Larnaca | - | Anorthosis Famagusta | 1:1 | ||||
| 19. Jornada | 29.01.2022 | Anorthosis Famagusta | - | Omonia Nikosia | 1:1 | ||||
| 20. Jornada | 06.02.2022 | Paphos FC | - | Anorthosis Famagusta | 1:1 | |
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| 15. Jornada | 10.02.2022 | Anorthosis Famagusta | - | Aris Limassol | 3:1 | ||||
| 21. Jornada | 14.02.2022 | Anorthosis Famagusta | - | Olympiacos Nikosia | 3:1 |  |
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| 16. Jornada | 17.02.2022 | APOEL Nikosia | - | Anorthosis Famagusta | 0:2 |
Chipre
Panamá