| 2. Jornada | 31.05.2021 | Philadelphia Union | - | Portland Timbers | 3:0 | ||||
| 4. Jornada | 23.07.2021 | Orlando City | - | Philadelphia Union | 2:1 | ||||
| 5. Jornada | 05.08.2021 | Philadelphia Union | - | Toronto FC | 3:0 | ||||
| 5. Jornada | 09.08.2021 | New England Revolution | - | Philadelphia Union | 2:1 |  |
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| 5. Jornada | 29.08.2021 | D.C. United | - | Philadelphia Union | 3:1 | ||||
| 6. Jornada | 04.09.2021 | Philadelphia Union | - | New England Revolution | 0:1 |  |
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| 6. Jornada | 25.09.2021 | Philadelphia Union | - | Atlanta United FC | 1:0 | ||||
| 6. Jornada | 30.09.2021 | New York RB | - | Philadelphia Union | 1:1 | ||||
| 7. Jornada | 10.10.2021 | FC Cincinnati | - | Philadelphia Union | 1:2 | |
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| 7. Jornada | 16.10.2021 | CF Montréal | - | Philadelphia Union | 2:2 | ||||
| 7. Jornada | 21.10.2021 | Minnesota United FC | - | Philadelphia Union | 3:2 | ||||
| 7. Jornada | 24.10.2021 | Philadelphia Union | - | Nashville SC | 1:0 | ||||
| 7. Jornada | 01.11.2021 | Philadelphia Union | - | FC Cincinnati | 2:0 | |
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| 8. Jornada | 07.11.2021 | New York City FC | - | Philadelphia Union | 1:1 |
Estados Unidos