| 3. Jornada | 21.01.2022 | Puebla FC [Sub 20] | - | Club Tijuana [Sub 20] | 0:2 | ||||
| 4. Jornada | 06.02.2022 | Gallos Blancos [Sub 20] | - | Puebla FC [Sub 20] | 0:2 | ||||
| 5. Jornada | 11.02.2022 | Puebla FC [Sub 20] | - | Atlas Guadalajara [Sub 20] | 1:2 | ||||
| 13. Jornada | 08.04.2022 | Puebla FC [Sub 20] | - | Pumas UNAM [Sub 20] | 2:2 | ||||
| 14. Jornada | 16.04.2022 | Club León [Sub 20] | - | Puebla FC [Sub 20] | 4:1 | ||||
| 15. Jornada | 19.04.2022 | CF Pachuca [Sub 20] | - | Puebla FC [Sub 20] | 2:2 |  |
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| 16. Jornada | 22.04.2022 | Puebla FC [Sub 20] | - | Club Necaxa [Sub 20] | 1:3 | ||||
| 17. Jornada | 29.04.2022 | Mazatlán FC [Sub 20] | - | Puebla FC [Sub 20] | 4:1 |
México