| 1. Jornada | 24.07.2021 | CF Pachuca [Sub 20] | - | Club León [Sub 20] | 0:1 | ||||
| 3. Jornada | 05.08.2021 | Gallos Blancos [Sub 20] | - | Club León [Sub 20] | 1:0 | ||||
| 7. Jornada | 28.08.2021 | Club León [Sub 20] | - | CF América [Sub 20] | 2:2 | ||||
| 10. Jornada | 25.09.2021 | Atlas Guadalajara [Sub 20] | - | Club León [Sub 20] | 2:1 | ||||
| 12. Jornada | 02.10.2021 | Club León [Sub 20] | - | Atlético San Luis [Sub 20] | 2:0 | ||||
| 13. Jornada | 16.10.2021 | CF Monterrey [Sub 20] | - | Club León [Sub 20] | 1:1 | ||||
| 14. Jornada | 20.10.2021 | Club León [Sub 20] | - | Pumas UNAM [Sub 20] | 0:2 |  |
|||
| 11. Jornada | 03.11.2021 | Cruz Azul [Sub 20] | - | Club León [Sub 20] | 2:0 |
México