| 1. Jornada | 24.07.2021 | Botev Plovdiv | - | Pirin Blagoevgrad | 2:1 | ||||
| 2. Jornada | 02.08.2021 | Pirin Blagoevgrad | - | PFC Beroe | 2:3 |  |
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| 4. Jornada | 13.08.2021 | Pirin Blagoevgrad | - | CSKA 1948 Sofia | 4:1 | ||||
| 5. Jornada | 22.08.2021 | CSKA Sofia | - | Pirin Blagoevgrad | 1:0 | ||||
| 6. Jornada | 29.08.2021 | Pirin Blagoevgrad | - | PFC Ludogorets Razgrad | 1:3 | ||||
| 7. Jornada | 10.09.2021 | Lokomotiv Sofia | - | Pirin Blagoevgrad | 2:1 | ||||
| 9. Jornada | 27.09.2021 | Pirin Blagoevgrad | - | Cherno More Varna | 2:2 | ||||
| 10. Jornada | 02.10.2021 | Slavia Sofia | - | Pirin Blagoevgrad | 1:1 | ||||
| 11. Jornada | 15.10.2021 | Pirin Blagoevgrad | - | Botev Vratsa | 3:1 | ||||
| 3. Jornada | 19.10.2021 | Lokomotiv Plovdiv | - | Pirin Blagoevgrad | 2:1 |
Bulgaria