| 1. Jornada | 17.02.2021 | Honduras Progreso | - | Marathón | 1:1 |  |
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| 2. Jornada | 21.02.2021 | Honduras Progreso | - | Vida | 0:0 |  |
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| 3. Jornada | 25.02.2021 | Real España | - | Honduras Progreso | 1:0 | ||||
| 4. Jornada | 01.03.2021 | Platense | - | Honduras Progreso | 0:4 | ||||
| 5. Jornada | 04.03.2021 | Honduras Progreso | - | Lobos UPNFM | 0:3 | ||||
| 6. Jornada | 07.03.2021 | Marathón | - | Honduras Progreso | 1:1 |  |
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| 9. Jornada | 22.03.2021 | Honduras Progreso | - | Platense | 2:2 | ||||
| 10. Jornada | 01.04.2021 | Lobos UPNFM | - | Honduras Progreso | 0:2 | |
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| 11. Jornada | 12.04.2021 | Motagua | - | Honduras Progreso | 5:2 | |
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| 12. Jornada | 18.04.2021 | Honduras Progreso | - | Olimpia | 0:5 | |
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| 13. Jornada | 21.04.2021 | Real Sociedad | - | Honduras Progreso | 3:1 | ||||
| 14. Jornada | 28.04.2021 | Honduras Progreso | - | Real de Minas | 5:2 | |
Colombia