| 1. Jornada | 31.07.2022 | Vida | - | Olimpia | 0:1 | ||||
| 2. Jornada | 07.08.2022 | Vida | - | Olancho FC | 1:0 | ||||
| 3. Jornada | 11.08.2022 | Motagua | - | Vida | 2:2 |  |
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| 4. Jornada | 14.08.2022 | Vida | - | Real Sociedad | 2:0 | |
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| 5. Jornada | 20.08.2022 | Marathón | - | Vida | 4:4 |  |
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| 6. Jornada | 27.08.2022 | Honduras Progreso | - | Vida | 0:1 | ||||
| 7. Jornada | 01.09.2022 | Vida | - | Real España | 1:0 | ||||
| 8. Jornada | 04.09.2022 | Victoria | - | Vida | 1:2 | ||||
| 9. Jornada | 11.09.2022 | Vida | - | Lobos UPNFM | 2:1 | |
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| 10. Jornada | 19.09.2022 | Olimpia | - | Vida | 2:0 |
Colombia