| 1. Jornada | 22.01.2022 | Diriangén FC | - | UNAN Managua | 4:0 | ||||
| 2. Jornada | 07.02.2022 | H&H Export Sébaco | - | UNAN Managua | 1:1 |  |
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| 3. Jornada | 10.02.2022 | UNAN Managua | - | ART Municipal Jalapa | 0:0 | ||||
| 4. Jornada | 13.02.2022 | Real Madriz | - | UNAN Managua | 0:1 |  |
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| 5. Jornada | 20.02.2022 | UNAN Managua | - | CD Walter Ferretti | 2:2 | ||||
| 6. Jornada | 28.02.2022 | Managua FC | - | UNAN Managua | 3:3 | |
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| 7. Jornada | 04.03.2022 | Real Estelí FC | - | UNAN Managua | 3:0 | |
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| 8. Jornada | 06.03.2022 | UNAN Managua | - | Club Deportivo Ocotal | 2:1 | ||||
| 9. Jornada | 11.03.2022 | UNAN Managua | - | Juventus Managua | 1:2 | |
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| 11. Jornada | 19.03.2022 | UNAN Managua | - | H&H Export Sébaco | 3:3 | ||||
| 12. Jornada | 04.04.2022 | ART Municipal Jalapa | - | UNAN Managua | 1:1 | |
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| 14. Jornada | 11.04.2022 | CD Walter Ferretti | - | UNAN Managua | 4:1 | |
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| 17. Jornada | 28.04.2022 | Club Deportivo Ocotal | - | UNAN Managua | 0:0 | ||||
| 18. Jornada | 02.05.2022 | Juventus Managua | - | UNAN Managua | 1:3 | |
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Brasil