| 1. Jornada | 26.07.2021 | Club Tijuana [Sub 20] | - | UANL Tigres [Sub 20] | 1:1 | ||||
| 2. Jornada | 31.07.2021 | Club León [Sub 20] | - | Club Tijuana [Sub 20] | 2:1 |  |
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| 4. Jornada | 13.08.2021 | FC Juárez [Sub 20] | - | Club Tijuana [Sub 20] | 1:3 | ||||
| 5. Jornada | 18.08.2021 | Club Tijuana [Sub 20] | - | Puebla FC [Sub 20] | 3:0 | ||||
| 8. Jornada | 11.09.2021 | Club Tijuana [Sub 20] | - | Santos Laguna [Sub 20] | 2:2 | ||||
| 12. Jornada | 04.10.2021 | Club Tijuana [Sub 20] | - | Cruz Azul [Sub 20] | 0:1 |  |
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| 14. Jornada | 21.10.2021 | Club Tijuana [Sub 20] | - | Deportivo Guadalajara [Sub 20] | 1:2 | ||||
| 15. Jornada | 24.10.2021 | Pumas UNAM [Sub 20] | - | Club Tijuana [Sub 20] | 4:0 | ||||
| 17. Jornada | 10.11.2021 | Club Tijuana [Sub 20] | - | CF Pachuca [Sub 20] | 2:1 |
México