| 1. Jornada | 08.01.2022 | Cruz Azul [Sub 20] | - | Club Tijuana [Sub 20] | 0:1 | ||||
| 6. Jornada | 19.02.2022 | Club Tijuana [Sub 20] | - | Club Necaxa [Sub 20] | 2:1 | ||||
| 7. Jornada | 26.02.2022 | Club Tijuana [Sub 20] | - | Atlas Guadalajara [Sub 20] | 2:1 | ||||
| 8. Jornada | 01.03.2022 | Deportivo Toluca [Sub 20] | - | Club Tijuana [Sub 20] | 3:1 | ||||
| 10. Jornada | 12.03.2022 | Santos Laguna [Sub 20] | - | Club Tijuana [Sub 20] | 4:2 | ||||
| 11. Jornada | 18.03.2022 | Club Tijuana [Sub 20] | - | FC Juárez [Sub 20] | 1:1 | ||||
| 14. Jornada | 16.04.2022 | Club Tijuana [Sub 20] | - | CF América [Sub 20] | 4:0 |  |
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| 15. Jornada | 19.04.2022 | Deportivo Guadalajara [Sub 20] | - | Club Tijuana [Sub 20] | 1:1 | ||||
| 17. Jornada | 30.04.2022 | CF Monterrey [Sub 20] | - | Club Tijuana [Sub 20] | 3:0 |
México