| 1. Jornada | 17.08.2018 | FC Twente | - | Sparta Rotterdam | 2:1 | ||||
| 2. Jornada | 24.08.2018 | Helmond Sport | - | FC Twente | 2:2 | ||||
| 3. Jornada | 31.08.2018 | FC Twente | - | Roda JC Kerkrade | 3:1 | ||||
| 4. Jornada | 08.09.2018 | FC Twente | - | TOP Oss | 1:2 | ||||
| 5. Jornada | 14.09.2018 | FC Dordrecht | - | FC Twente | 0:2 |  |
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| 6. Jornada | 21.09.2018 | Telstar | - | FC Twente | 1:3 | ||||
| 7. Jornada | 30.09.2018 | FC Twente | - | Jong PSV | 2:1 | ||||
| 8. Jornada | 05.10.2018 | FC Eindhoven | - | FC Twente | 1:1 | ||||
| 9. Jornada | 14.10.2018 | FC Twente | - | MVV | 0:1 | |
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| 10. Jornada | 22.10.2018 | FC Utrecht (J) | - | FC Twente | 1:6 | ||||
| 11. Jornada | 26.10.2018 | FC Twente | - | Almere City FC | 1:0 | ||||
| 12. Jornada | 02.11.2018 | FC Twente | - | RKC Waalwijk | 3:1 | ||||
| 13. Jornada | 09.11.2018 | FC Den Bosch | - | FC Twente | 2:1 | |
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| 17. Jornada | 07.12.2018 | FC Volendam | - | FC Twente | 1:2 | ||||
| 23. Jornada | 01.02.2019 | FC Twente | - | Helmond Sport | 4:1 | ||||
| 25. Jornada | 18.02.2019 | Jong PSV | - | FC Twente | 0:2 | ||||
| 26. Jornada | 22.02.2019 | FC Twente | - | FC Eindhoven | 1:0 | ||||
| 35. Jornada | 29.04.2019 | Jong Ajax | - | FC Twente | 2:5 | ||||
| 38. Jornada | 03.05.2019 | FC Twente | - | SC Cambuur | 2:2 |
Portugal