| 1. Jornada | 14.08.2021 | Heracles Almelo | - | PSV | 0:2 | ||||
| 2. Jornada | 21.08.2021 | Sparta Rotterdam | - | Heracles Almelo | 1:1 |  |
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| 3. Jornada | 29.08.2021 | Heracles Almelo | - | NEC Nijmegen | 0:1 | ||||
| 5. Jornada | 19.09.2021 | Heracles Almelo | - | AZ Alkmaar | 3:2 |  |
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| 6. Jornada | 23.09.2021 | SC Cambuur | - | Heracles Almelo | 2:1 | ||||
| 7. Jornada | 26.09.2021 | Heracles Almelo | - | RKC Waalwijk | 1:0 | ||||
| 8. Jornada | 02.10.2021 | Heracles Almelo | - | Willem II | 3:2 | |
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| 9. Jornada | 16.10.2021 | Go Ahead Eagles | - | Heracles Almelo | 4:2 | |
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| 10. Jornada | 23.10.2021 | PEC Zwolle | - | Heracles Almelo | 1:0 | |
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| 11. Jornada | 30.10.2021 | Heracles Almelo | - | AFC Ajax | 0:0 | ||||
| 12. Jornada | 05.11.2021 | FC Twente | - | Heracles Almelo | 1:0 | ||||
| 19. Jornada | 15.01.2022 | NEC Nijmegen | - | Heracles Almelo | 0:0 |
Países Bajos