| 5. Jornada | 16.08.2021 | Nashville SC | - | D.C. United | 5:2 | ||||
| 5. Jornada | 19.08.2021 | New England Revolution | - | D.C. United | 3:2 |  |
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| 5. Jornada | 22.08.2021 | D.C. United | - | Atlanta United FC | 1:2 | ||||
| 5. Jornada | 29.08.2021 | D.C. United | - | Philadelphia Union | 3:1 | |
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| 6. Jornada | 12.09.2021 | New York RB | - | D.C. United | 1:1 | ||||
| 6. Jornada | 16.09.2021 | D.C. United | - | Chicago Fire | 3:0 | ||||
| 7. Jornada | 17.10.2021 | D.C. United | - | Nashville SC | 0:0 | ||||
| 7. Jornada | 21.10.2021 | D.C. United | - | New England Revolution | 2:3 | |
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| 7. Jornada | 24.10.2021 | New York City FC | - | D.C. United | 6:0 | ||||
| 7. Jornada | 28.10.2021 | D.C. United | - | New York RB | 1:0 | ||||
| 7. Jornada | 31.10.2021 | D.C. United | - | Columbus Crew | 1:3 | ||||
| 8. Jornada | 07.11.2021 | Toronto FC | - | D.C. United | 1:3 |
Argentina
