| 3. Jornada | 08.08.2021 | Pumas UNAM [Sub 18] | - | Atlético San Luis [Sub 18] | 1:1 | ||||
| 7. Jornada | 29.08.2021 | Deportivo Toluca [Sub 18] | - | Pumas UNAM [Sub 18] | 2:0 |  |
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| 9. Jornada | 18.09.2021 | Mazatlán FC [Sub 18] | - | Pumas UNAM [Sub 18] | 2:0 | ||||
| 10. Jornada | 25.09.2021 | UANL Tigres [Sub 18] | - | Pumas UNAM [Sub 18] | 6:0 |
México