| 1. Jornada | 11.07.2022 | Diriangén FC | - | Matagalpa FC | 2:0 | ||||
| 2. Jornada | 17.07.2022 | Matagalpa FC | - | ART Municipal Jalapa | 0:0 | ||||
| 3. Jornada | 25.07.2022 | Juventus Managua | - | Matagalpa FC | 3:2 | ||||
| 4. Jornada | 31.07.2022 | Matagalpa FC | - | H&H Export Sébaco | 1:2 |  |
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| 5. Jornada | 07.08.2022 | Club Deportivo Ocotal | - | Matagalpa FC | 1:1 | ||||
| 6. Jornada | 11.08.2022 | Matagalpa FC | - | CD Walter Ferretti | 1:0 | ||||
| 8. Jornada | 21.08.2022 | Matagalpa FC | - | Managua FC | 1:0 | |
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| 9. Jornada | 28.08.2022 | Matagalpa FC | - | Real Estelí FC | 0:3 | ||||
| 10. Jornada | 04.09.2022 | Matagalpa FC | - | Diriangén FC | 2:3 | |
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| 11. Jornada | 11.09.2022 | ART Municipal Jalapa | - | Matagalpa FC | 2:1 | ||||
| 12. Jornada | 01.10.2022 | Matagalpa FC | - | Juventus Managua | 2:5 | ||||
| 13. Jornada | 23.10.2022 | H&H Export Sébaco | - | Matagalpa FC | 2:1 | |
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| 15. Jornada | 30.10.2022 | CD Walter Ferretti | - | Matagalpa FC | 1:0 | |
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| 18. Jornada | 02.12.2022 | Real Estelí FC | - | Matagalpa FC | 6:0 | |
Nicaragua