| 3. Jornada | 25.09.2020 | FC Twente | - | FC Groningen | 3:1 | ||||
| 4. Jornada | 04.10.2020 | FC Groningen | - | AFC Ajax | 1:0 |  |
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| 6. Jornada | 25.10.2020 | Fortuna Sittard | - | FC Groningen | 1:3 | ||||
| 7. Jornada | 31.10.2020 | FC Groningen | - | VVV-Venlo | 2:1 | ||||
| 8. Jornada | 08.11.2020 | Feyenoord | - | FC Groningen | 2:0 |  |
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| 9. Jornada | 21.11.2020 | FC Groningen | - | Vitesse | 1:1 | ||||
| 11. Jornada | 06.12.2020 | AZ Alkmaar | - | FC Groningen | 1:2 | ||||
| 12. Jornada | 12.12.2020 | FC Groningen | - | RKC Waalwijk | 2:0 | |
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| 14. Jornada | 23.12.2020 | FC Groningen | - | Heracles Almelo | 0:1 | ||||
| 15. Jornada | 09.01.2021 | FC Utrecht | - | FC Groningen | 2:2 | ||||
| 17. Jornada | 17.01.2021 | FC Groningen | - | FC Twente | 2:2 |
Países Bajos