| Grupo F | 16.09.2021 | Crvena Zvezda | - | Sporting Braga | 2:1 | ||||
| Grupo F | 30.09.2021 | Sporting Braga | - | FC Midtjylland | 3:1 |  |
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| Grupo F | 21.10.2021 | PFC Ludogorets Razgrad | - | Sporting Braga | 0:1 | |
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| Grupo F | 04.11.2021 | Sporting Braga | - | PFC Ludogorets Razgrad | 4:2 | ||||
| Grupo F | 25.11.2021 | FC Midtjylland | - | Sporting Braga | 3:2 | |
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| Grupo F | 09.12.2021 | Sporting Braga | - | Crvena Zvezda | 1:1 | ||||
| Playoffs | 17.02.2022 | FC Sheriff | - | Sporting Braga | 2:0 | ||||
| Playoffs | 24.02.2022 | Sporting Braga | - | FC Sheriff | 3:2 pn. | |
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| Octavos de final | 10.03.2022 | Sporting Braga | - | Mónaco | 2:0 | ||||
| Octavos de final | 17.03.2022 | Mónaco | - | Sporting Braga | 1:1 | ||||
| Cuartos de final | 07.04.2022 | Sporting Braga | - | Rangers FC | 1:0 | ||||
| Cuartos de final | 14.04.2022 | Rangers FC | - | Sporting Braga | 3:1 pró. |  |
Portugal