| 1. Jornada | 19.09.2021 | Colima FC | - | Mazorqueros | 1:2 | ||||
| 2. Jornada | 25.09.2021 | Tecos Fútbol Club | - | Colima FC | 1:1 |  |
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| 3. Jornada | 02.10.2021 | Correcaminos UAT II | - | Colima FC | 0:0 | ||||
| 6. Jornada | 17.10.2021 | Colima FC | - | Mineros de Fresnillo FC | 5:0 | ||||
| 8. Jornada | 31.10.2021 | Colima FC | - | Alacranes de Durango | 1:0 | ||||
| 11. Jornada | 13.11.2021 | Tritones Vallarta | - | Colima FC | 3:0 |
México