| 3. Jornada | 21.01.2022 | Mazatlán FC [Sub 20] | - | Deportivo Toluca [Sub 20] | 1:0 | ||||
| 4. Jornada | 06.02.2022 | UANL Tigres [Sub 20] | - | Mazatlán FC [Sub 20] | 3:2 | ||||
| 7. Jornada | 24.02.2022 | CF Pachuca [Sub 20] | - | Mazatlán FC [Sub 20] | 3:2 | ||||
| 8. Jornada | 01.03.2022 | Mazatlán FC [Sub 20] | - | Club Necaxa [Sub 20] | 1:3 | ||||
| 10. Jornada | 11.03.2022 | CF Monterrey [Sub 20] | - | Mazatlán FC [Sub 20] | 2:3 | ||||
| 12. Jornada | 01.04.2022 | Atlético San Luis [Sub 20] | - | Mazatlán FC [Sub 20] | 1:2 |
México