| 12. Jornada | 16.09.2021 | Rocha | - | Defensor Sporting | 1:2 | ||||
| 13. Jornada | 23.09.2021 | Defensor Sporting | - | CA Cerro | 2:0 | ||||
| 14. Jornada | 30.09.2021 | Defensor Sporting | - | Albion | 0:1 | ||||
| 15. Jornada | 05.10.2021 | Central Español | - | Defensor Sporting | 1:0 | ||||
| 16. Jornada | 12.10.2021 | Defensor Sporting | - | Atenas | 1:1 |  |
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| 19. Jornada | 02.11.2021 | Juventud de Las Piedras | - | Defensor Sporting | 3:3 |
Uruguay