| 1. Jornada | 31.01.2010 | Club Rubio Ñu | - | Club Olimpia | 1:0 | ||||
| 2. Jornada | 06.02.2010 | Libertad | - | Club Rubio Ñu | 2:1 |  |
|||
| 3. Jornada | 12.02.2010 | Club Rubio Ñu | - | Guaraní | 1:1 | |
|||
| 5. Jornada | 21.02.2010 | Tacuary | - | Club Rubio Ñu | 0:1 | ||||
| 6. Jornada | 01.03.2010 | Club Rubio Ñu | - | Club Nacional | 4:1 | ||||
| 7. Jornada | 07.03.2010 | Sportivo Trinidense | - | Club Rubio Ñu | 1:1 | |
|||
| 10. Jornada | 21.03.2010 | Club Rubio Ñu | - | Sport Colombia | 2:1 |  |
|||
| 11. Jornada | 27.03.2010 | Cerro Porteño | - | Club Rubio Ñu | 1:1 | |
|||
| 12. Jornada | 04.04.2010 | Club Olimpia | - | Club Rubio Ñu | 1:1 | |
|||
| 13. Jornada | 10.04.2010 | Club Rubio Ñu | - | Libertad | 2:1 | ||||
| 14. Jornada | 15.04.2010 | Guaraní | - | Club Rubio Ñu | 3:2 | |
|||
| 16. Jornada | 25.04.2010 | Club Rubio Ñu | - | Tacuary | 3:1 | |
|||
| 21. Jornada | 23.05.2010 | Sport Colombia | - | Club Rubio Ñu | 2:4 | |
Argentina