| 3. Jornada | 02.02.2019 | Deportivo Santaní | - | River Plate | 1:1 |  |
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| 4. Jornada | 05.02.2019 | River Plate | - | Sol de América | 1:0 | ||||
| 5. Jornada | 11.02.2019 | Cerro Porteño | - | River Plate | 3:1 |  |
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| 6. Jornada | 17.02.2019 | River Plate | - | Libertad | 1:1 | ||||
| 7. Jornada | 23.02.2019 | Deportivo Capiatá | - | River Plate | 3:3 | |
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| 8. Jornada | 27.02.2019 | River Plate | - | General Díaz | 3:2 | ||||
| 9. Jornada | 04.03.2019 | Guaraní | - | River Plate | 2:1 | |
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| 11. Jornada | 16.03.2019 | River Plate | - | Club Nacional | 1:1 | ||||
| 12. Jornada | 24.03.2019 | River Plate | - | San Lorenzo | 2:1 | ||||
| 13. Jornada | 01.04.2019 | Sportivo Luqueño | - | River Plate | 3:1 | ||||
| 14. Jornada | 04.04.2019 | River Plate | - | Deportivo Santaní | 1:2 | ||||
| 16. Jornada | 14.04.2019 | River Plate | - | Cerro Porteño | 1:5 | ||||
| 17. Jornada | 21.04.2019 | Libertad | - | River Plate | 2:1 | |
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| 18. Jornada | 28.04.2019 | River Plate | - | Deportivo Capiatá | 1:0 | ||||
| 19. Jornada | 01.05.2019 | General Díaz | - | River Plate | 0:1 | ||||
| 20. Jornada | 07.05.2019 | River Plate | - | Guaraní | 0:1 | ||||
| 21. Jornada | 14.05.2019 | River Plate | - | Club Olimpia | 2:2 | |
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| 22. Jornada | 19.05.2019 | Club Nacional | - | River Plate | 0:0 | |
Paraguay