| 1. Jornada | 31.01.2010 | Sportivo Luqueño | - | Sport Colombia | 2:3 | ||||
| 2. Jornada | 07.02.2010 | Sport Colombia | - | Sportivo Trinidense | 0:0 |  |
|||
| 3. Jornada | 13.02.2010 | Club Nacional | - | Sport Colombia | 1:2 | ||||
| 4. Jornada | 17.02.2010 | Sport Colombia | - | 3 de Febrero | 2:3 | ||||
| 5. Jornada | 21.02.2010 | Sol de América | - | Sport Colombia | 1:2 | ||||
| 9. Jornada | 17.03.2010 | Sport Colombia | - | Guaraní | 1:3 | ||||
| 13. Jornada | 10.04.2010 | Sportivo Trinidense | - | Sport Colombia | 1:0 | ||||
| 14. Jornada | 14.04.2010 | Sport Colombia | - | Club Nacional | 1:0 | ||||
| 15. Jornada | 18.04.2010 | 3 de Febrero | - | Sport Colombia | 2:0 | ||||
| 16. Jornada | 25.04.2010 | Sport Colombia | - | Sol de América | 2:2 | ||||
| 17. Jornada | 03.05.2010 | Sport Colombia | - | Libertad | 0:1 | ||||
| 18. Jornada | 09.05.2010 | Club Olimpia | - | Sport Colombia | 2:1 |  |
|||
| 22. Jornada | 28.05.2010 | Tacuary | - | Sport Colombia | 2:2 |
Paraguay