| Grupo B | 14.09.2011 | Colorado Rapids | - | Santos Laguna | 1:4 | ||||
| Grupo B | 23.09.2011 | Santos Laguna | - | Isidro Metapán | 6:0 | ||||
| Cuartos de final | 08.03.2012 | Seattle Sounders | - | Santos Laguna | 2:1 | ||||
| Cuartos de final | 15.03.2012 | Santos Laguna | - | Seattle Sounders | 6:1 | ||||
| Semifinales | 29.03.2012 | Toronto FC | - | Santos Laguna | 1:1 | ||||
| Final | 19.04.2012 | CF Monterrey | - | Santos Laguna | 2:0 |  |
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| Final | 26.04.2012 | Santos Laguna | - | CF Monterrey | 2:1 |
México