| 1. Jornada | 18.01.2009 | Monarcas Morelia | - | Club San Luis | 0:0 | ||||
| 2. Jornada | 25.01.2009 | Club San Luis | - | CF Pachuca | 1:2 | ||||
| 3. Jornada | 01.02.2009 | Jaguares Chiapas | - | Club San Luis | 1:2 | ||||
| 4. Jornada | 07.02.2009 | Club San Luis | - | Atlas Guadalajara | 2:1 | ||||
| 5. Jornada | 15.02.2009 | UANL Tigres | - | Club San Luis | 1:0 | ||||
| 8. Jornada | 01.03.2009 | CF América | - | Club San Luis | 0:2 | ||||
| 9. Jornada | 08.03.2009 | Club San Luis | - | Pumas UNAM | 0:2 | ||||
| 10. Jornada | 15.03.2009 | Puebla FC | - | Club San Luis | 2:1 | ||||
| 11. Jornada | 22.03.2009 | Club San Luis | - | Indios Juárez | 4:1 | ||||
| 12. Jornada | 05.04.2009 | Deportivo Guadalajara | - | Club San Luis | 1:0 | ||||
| 13. Jornada | 12.04.2009 | Club San Luis | - | UAG Tecos | 3:3 | ||||
| 14. Jornada | 19.04.2009 | CF Monterrey | - | Club San Luis | 1:0 |  |
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| 15. Jornada | 25.04.2009 | Club San Luis | - | Club Necaxa | 1:1 | ||||
| 16. Jornada | 03.05.2009 | Santos Laguna | - | Club San Luis | 3:1 | |
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| 17. Jornada | 10.05.2009 | Club San Luis | - | Deportivo Toluca | 1:5 |  |
México