| 2. Jornada | 15.01.2022 | Deportivo Toluca [] | - | Club Necaxa [] | 2:1 | ||||
| 6. Jornada | 12.02.2022 | Club Necaxa [] | - | CF Pachuca [] | 2:1 | ||||
| 7. Jornada | 19.02.2022 | CF América [] | - | Club Necaxa [] | 3:3 | ||||
| 8. Jornada | 26.02.2022 | Club Necaxa [] | - | Gallos Blancos [] | 3:1 | ||||
| 9. Jornada | 05.03.2022 | Pumas UNAM [] | - | Club Necaxa [] | 1:1 | ||||
| 11. Jornada | 19.03.2022 | Club Necaxa [] | - | Deportivo Toluca [] | 3:4 | ||||
| 14. Jornada | 09.04.2022 | CF Pachuca [] | - | Club Necaxa [] | 0:1 | ||||
| 15. Jornada | 16.04.2022 | Gallos Blancos [] | - | Club Necaxa [] | 2:3 | ||||
| 18. Jornada | 07.05.2022 | Cruz Azul [] | - | Club Necaxa [] | 1:3 |
México