| 4. Jornada | 21.02.2021 | Guaraní | - | Club Olimpia | 0:3 | ||||
| 8. Jornada | 14.03.2021 | Guaraní | - | Guaireña FC | 0:3 | ||||
| 9. Jornada | 21.03.2021 | Cerro Porteño | - | Guaraní | 2:1 | ||||
| 7. Jornada | 29.03.2021 | Libertad | - | Guaraní | 1:1 |  |
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| 11. Jornada | 13.04.2021 | Guaraní | - | River Plate | 2:0 | |
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| 12. Jornada | 17.04.2021 | 12 de Octubre de Itauguá | - | Guaraní | 1:1 | |
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| 13. Jornada | 25.04.2021 | Club Olimpia | - | Guaraní | 2:1 | ||||
| 15. Jornada | 08.05.2021 | Sportivo Luqueño | - | Guaraní | 1:2 | ||||
| 16. Jornada | 17.05.2021 | Guaraní | - | Libertad | 1:6 | ||||
| 18. Jornada | 29.05.2021 | Guaraní | - | Cerro Porteño | 2:0 |
Uruguay