| 4. Jornada | 14.08.2021 | Cruz Azul [Sub 20] | - | Deportivo Toluca [Sub 20] | 2:2 |  |
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| 5. Jornada | 18.08.2021 | Cruz Azul [Sub 20] | - | CF Monterrey [Sub 20] | 2:1 | ||||
| 6. Jornada | 21.08.2021 | Atlético San Luis [Sub 20] | - | Cruz Azul [Sub 20] | 0:0 | ||||
| 10. Jornada | 24.09.2021 | Puebla FC [Sub 20] | - | Cruz Azul [Sub 20] | 0:0 | ||||
| 12. Jornada | 04.10.2021 | Club Tijuana [Sub 20] | - | Cruz Azul [Sub 20] | 0:1 | ||||
| 13. Jornada | 16.10.2021 | Cruz Azul [Sub 20] | - | UANL Tigres [Sub 20] | 1:0 | ||||
| 15. Jornada | 23.10.2021 | Deportivo Guadalajara [Sub 20] | - | Cruz Azul [Sub 20] | 0:1 | ||||
| 16. Jornada | 31.10.2021 | Cruz Azul [Sub 20] | - | CF América [Sub 20] | 1:1 | ||||
| 11. Jornada | 03.11.2021 | Cruz Azul [Sub 20] | - | Club León [Sub 20] | 2:0 | ||||
| 17. Jornada | 07.11.2021 | Pumas UNAM [Sub 20] | - | Cruz Azul [Sub 20] | 1:2 | |
México