| 1. Jornada | 25.08.2010 | River Plate | - | Defensor Sporting | 1:1 |  |
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| 2. Jornada | 29.08.2010 | Defensor Sporting | - | Liverpool | 3:0 | |
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| 4. Jornada | 19.09.2010 | Defensor Sporting | - | Montevideo Wanderers | 1:2 | ||||
| 6. Jornada | 02.10.2010 | Defensor Sporting | - | Bella Vista | 1:2 | ||||
| 3. Jornada | 06.10.2010 | Defensor Sporting | - | CA Cerro | 2:0 | ||||
| 7. Jornada | 09.10.2010 | Miramar Misiones | - | Defensor Sporting | 0:1 | |
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| 5. Jornada | 12.10.2010 | Defensor Sporting | - | El Tanque Sisley | 3:1 | |
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| 8. Jornada | 16.10.2010 | Danubio | - | Defensor Sporting | 1:1 | |
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| 9. Jornada | 24.10.2010 | Defensor Sporting | - | Rampla Juniors | 4:1 | |
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| 10. Jornada | 31.10.2010 | Defensor Sporting | - | Fénix | 5:1 | |
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| 11. Jornada | 06.11.2010 | Racing | - | Defensor Sporting | 0:3 | |
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| 12. Jornada | 13.11.2010 | Defensor Sporting | - | Central Español | 1:1 | ||||
| 13. Jornada | 20.11.2010 | Peñarol | - | Defensor Sporting | 0:1 | ||||
| 14. Jornada | 27.11.2010 | Defensor Sporting | - | Nacional | 1:2 | |
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| 15. Jornada | 05.12.2010 | Tacuarembó | - | Defensor Sporting | 1:3 | |
Uruguay
