| 2. Jornada | 15.01.2022 | CF Monterrey [Sub 16] | - | Deportivo Guadalajara [Sub 16] | 2:2 | ||||
| 7. Jornada | 19.02.2022 | Deportivo Guadalajara [Sub 16] | - | Mazatlán FC [Sub 16] | 7:1 | ||||
| 10. Jornada | 12.03.2022 | Atlético San Luis [Sub 16] | - | Deportivo Guadalajara [Sub 16] | 0:1 | ||||
| 15. Jornada | 30.03.2022 | Deportivo Guadalajara [Sub 16] | - | CF Monterrey [Sub 16] | 5:1 | ||||
| 14. Jornada | 09.04.2022 | Mazatlán FC [Sub 16] | - | Deportivo Guadalajara [Sub 16] | 1:2 | ||||
| 17. Jornada | 30.04.2022 | Deportivo Guadalajara [Sub 16] | - | Santos Laguna [Sub 16] | 3:0 | ||||
| 18. Jornada | 07.05.2022 | Deportivo Guadalajara [Sub 16] | - | UANL Tigres [Sub 16] | 4:3 |
México