| 1. Jornada | 18.01.2021 | Defensor Sporting | - | Montevideo Wanderers | 1:1 | ||||
| 2. Jornada | 28.01.2021 | Peñarol | - | Defensor Sporting | 1:2 |  |
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| 3. Jornada | 01.02.2021 | Defensor Sporting | - | River Plate | 0:2 | |
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| 5. Jornada | 07.02.2021 | Defensor Sporting | - | Plaza Colonia | 3:2 | ||||
| 6. Jornada | 11.02.2021 | Progreso | - | Defensor Sporting | 3:3 | ||||
| 11. Jornada | 08.03.2021 | Nacional | - | Defensor Sporting | 2:1 | ||||
| 12. Jornada | 12.03.2021 | Defensor Sporting | - | Boston River | 1:2 | ||||
| 13. Jornada | 18.03.2021 | Deportivo Maldonado | - | Defensor Sporting | 2:1 |  |
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| 14. Jornada | 25.03.2021 | Defensor Sporting | - | Rentistas | 0:0 | ||||
| 15. Jornada | 29.03.2021 | Cerro Largo | - | Defensor Sporting | 0:0 | |
Uruguay