| 2. Jornada | 31.07.2021 | CF América [Sub 18] | - | Club Necaxa [Sub 18] | 2:3 |  |
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| 3. Jornada | 06.08.2021 | Club Necaxa [Sub 18] | - | Cruz Azul [Sub 18] | 5:0 | |
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| 4. Jornada | 12.08.2021 | Atlético San Luis [Sub 18] | - | Club Necaxa [Sub 18] | 3:3 | ||||
| 5. Jornada | 17.08.2021 | Club Necaxa [Sub 18] | - | Pumas UNAM [Sub 18] | 4:2 | ||||
| 6. Jornada | 22.08.2021 | Club Necaxa [Sub 18] | - | FC Juárez [Sub 18] | 3:2 | ||||
| 7. Jornada | 28.08.2021 | Deportivo Guadalajara [Sub 18] | - | Club Necaxa [Sub 18] | 1:2 | ||||
| 8. Jornada | 12.09.2021 | Gallos Blancos [Sub 18] | - | Club Necaxa [Sub 18] | 1:1 | ||||
| 16. Jornada | 29.10.2021 | Club Necaxa [Sub 18] | - | Mazatlán FC [Sub 18] | 3:0 |
México