| 1. Jornada | 25.07.2010 | Universitario de Sucre | - | Club San José | 2:2 |  |
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| 2. Jornada | 01.08.2010 | Club San José | - | Blooming | 2:0 | |
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| 3. Jornada | 08.08.2010 | Jorge Wilstermann | - | Club San José | 1:3 | ||||
| 4. Jornada | 15.08.2010 | Club San José | - | The Strongest | 3:2 | ||||
| 5. Jornada | 22.08.2010 | CD Guabirá | - | Club San José | 3:1 | ||||
| 6. Jornada | 28.08.2010 | Club San José | - | Real Potosí | 2:3 | |
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| 7. Jornada | 05.09.2010 | Oriente Petrolero | - | Club San José | 2:1 | ||||
| 8. Jornada | 11.09.2010 | Club San José | - | Club Aurora | 3:3 | ||||
| 9. Jornada | 12.09.2010 | Bolívar | - | Club San José | 0:0 | |
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| 10. Jornada | 18.09.2010 | Club San José | - | Real Mamoré | 1:0 | ||||
| 11. Jornada | 25.09.2010 | La Paz FC | - | Club San José | 4:3 | |
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| 14. Jornada | 10.10.2010 | Club San José | - | Jorge Wilstermann | 2:0 | ||||
| 15. Jornada | 17.10.2010 | The Strongest | - | Club San José | 1:2 |
Bolivia