| 9. Jornada | 10.04.2022 | Sportivo Ameliano | - | Guaraní | 0:1 |  |
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| 10. Jornada | 17.04.2022 | Guaraní | - | Club Nacional | 0:1 | ||||
| 17. Jornada | 22.05.2022 | General Caballero DJLM | - | Guaraní | 0:4 |  |
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| 18. Jornada | 14.06.2022 | Guaraní | - | Libertad | 1:1 | ||||
| 19. Jornada | 20.06.2022 | Tacuary | - | Guaraní | 0:2 | |
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| 20. Jornada | 23.06.2022 | Guaraní | - | Sportivo Ameliano | 1:1 | ||||
| 21. Jornada | 27.06.2022 | Club Nacional | - | Guaraní | 0:1 | ||||
| 22. Jornada | 04.07.2022 | Guaraní | - | Club Olimpia | 0:2 |
Paraguay