| 1. Jornada | 22.01.2022 | CD Walter Ferretti | - | Real Madriz | 3:0 |  |
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| 2. Jornada | 06.02.2022 | Club Deportivo Ocotal | - | CD Walter Ferretti | 1:0 | |
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| 3. Jornada | 10.02.2022 | CD Walter Ferretti | - | Diriangén FC | 2:3 | ||||
| 4. Jornada | 14.02.2022 | ART Municipal Jalapa | - | CD Walter Ferretti | 3:2 | |
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| 5. Jornada | 20.02.2022 | UNAN Managua | - | CD Walter Ferretti | 2:2 | |
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| 9. Jornada | 11.03.2022 | Managua FC | - | CD Walter Ferretti | 2:1 | |
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| 13. Jornada | 08.04.2022 | CD Walter Ferretti | - | ART Municipal Jalapa | 4:1 | ||||
| 14. Jornada | 11.04.2022 | CD Walter Ferretti | - | UNAN Managua | 4:1 |
Nicaragua