| 1. Jornada | 07.08.2021 | Tranmere Rovers | - | Walsall FC | 1:0 | ||||
| 2. Jornada | 14.08.2021 | Port Vale FC | - | Tranmere Rovers | 0:0 | ||||
| 3. Jornada | 17.08.2021 | Swindon Town | - | Tranmere Rovers | 0:0 | ||||
| 4. Jornada | 21.08.2021 | Tranmere Rovers | - | Newport County | 0:1 | ||||
| 5. Jornada | 28.08.2021 | Scunthorpe United | - | Tranmere Rovers | 1:0 | ||||
| 6. Jornada | 04.09.2021 | Tranmere Rovers | - | Hartlepool United | 1:0 | ||||
| 7. Jornada | 11.09.2021 | Rochdale AFC | - | Tranmere Rovers | 1:0 |  |
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| 9. Jornada | 25.09.2021 | Forest Green Rovers | - | Tranmere Rovers | 0:0 | ||||
| 11. Jornada | 08.10.2021 | Tranmere Rovers | - | Colchester United | 2:0 | ||||
| 12. Jornada | 16.10.2021 | Carlisle United | - | Tranmere Rovers | 0:1 | ||||
| 14. Jornada | 23.10.2021 | Tranmere Rovers | - | Northampton Town | 0:2 | ||||
| 16. Jornada | 13.11.2021 | Tranmere Rovers | - | Sutton United | 0:1 | ||||
| 18. Jornada | 23.11.2021 | Tranmere Rovers | - | Bradford City | 2:1 | ||||
| 22. Jornada | 18.12.2021 | Tranmere Rovers | - | Leyton Orient | 1:0 | ||||
| 23. Jornada | 26.12.2021 | Tranmere Rovers | - | Barrow AFC | 2:0 | ||||
| 26. Jornada | 08.01.2022 | Tranmere Rovers | - | Scunthorpe United | 4:0 |  |
Inglaterra