| 1. Jornada | 17.02.2021 | Honduras Progreso | - | Marathón | 1:1 |  |
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| 2. Jornada | 20.02.2021 | Marathón | - | Motagua | 0:1 | ||||
| 3. Jornada | 25.02.2021 | Vida | - | Marathón | 0:1 |  |
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| 4. Jornada | 27.02.2021 | Marathón | - | Real España | 1:2 | |
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| 5. Jornada | 04.03.2021 | Platense | - | Marathón | 5:3 | ||||
| 6. Jornada | 07.03.2021 | Marathón | - | Honduras Progreso | 1:1 | ||||
| 7. Jornada | 12.03.2021 | Motagua | - | Marathón | 2:0 | ||||
| 8. Jornada | 17.03.2021 | Marathón | - | Vida | 1:2 | ||||
| 9. Jornada | 21.03.2021 | Real España | - | Marathón | 2:2 | ||||
| 10. Jornada | 03.04.2021 | Marathón | - | Platense | 1:0 | |
Argentina
Brasil