| 4. Jornada | 25.09.2021 | Hapoel Be'er Sheva | - | Maccabi Tel Aviv | 2:0 | ||||
| 10. Jornada | 27.11.2021 | Ironi Kiryat Shmona | - | Hapoel Be'er Sheva | 1:2 | ||||
| 11. Jornada | 01.12.2021 | Hapoel Be'er Sheva | - | Hapoel Tel Aviv | 2:1 | ||||
| 12. Jornada | 06.12.2021 | Hapoel Haifa | - | Hapoel Be'er Sheva | 0:1 | ||||
| 13. Jornada | 12.12.2021 | Hapoel Be'er Sheva | - | Hapoel Nof HaGalil | 2:0 | ||||
| 14. Jornada | 22.12.2021 | Hapoel Be'er Sheva | - | Beitar Jerusalem | 3:1 | ||||
| 15. Jornada | 26.12.2021 | Hapoel Hadera | - | Hapoel Be'er Sheva | 1:2 | ||||
| 16. Jornada | 02.01.2022 | Hapoel Be'er Sheva | - | Bnei Sachnin FC | 3:0 |  |
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| 17. Jornada | 08.01.2022 | Maccabi Tel Aviv | - | Hapoel Be'er Sheva | 1:0 | ||||
| 20. Jornada | 29.01.2022 | Hapoel Jerusalem | - | Hapoel Be'er Sheva | 0:1 | |
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| 21. Jornada | 05.02.2022 | Hapoel Be'er Sheva | - | Maccabi Netanya | 0:1 | ||||
| 22. Jornada | 12.02.2022 | FC Ashdod | - | Hapoel Be'er Sheva | 1:1 |  |
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| 23. Jornada | 19.02.2022 | Hapoel Be'er Sheva | - | Ironi Kiryat Shmona | 0:0 | ||||
| 24. Jornada | 26.02.2022 | Hapoel Tel Aviv | - | Hapoel Be'er Sheva | 1:1 | |
Israel