| 1. Jornada | 08.08.2021 | FK Renova | - | FK Skopje | 1:1 | ||||
| 2. Jornada | 15.08.2021 | KF Shkëndija 79 | - | FK Renova | 1:2 |  |
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| 3. Jornada | 18.08.2021 | FK Renova | - | FK Borec | 2:0 | ||||
| 4. Jornada | 22.08.2021 | FK AP Brera Strumica | - | FK Renova | 2:1 | ||||
| 6. Jornada | 12.09.2021 | GFK Tikvesh | - | FK Renova | 0:2 | ||||
| 7. Jornada | 19.09.2021 | FK Renova | - | FC Struga | 1:0 | ||||
| 9. Jornada | 02.10.2021 | Makedonija GP | - | FK Renova | 1:1 | ||||
| 11. Jornada | 23.10.2021 | KF Shkupi | - | FK Renova | 2:1 | ||||
| 12. Jornada | 30.10.2021 | FK Skopje | - | FK Renova | 0:0 | ||||
| 13. Jornada | 06.11.2021 | FK Renova | - | KF Shkëndija 79 | 0:1 | ||||
| 14. Jornada | 21.11.2021 | FK Borec | - | FK Renova | 1:4 | ||||
| 15. Jornada | 27.11.2021 | FK Renova | - | FK AP Brera Strumica | 1:2 | ||||
| 16. Jornada | 04.12.2021 | FK Rabotnički | - | FK Renova | 0:0 | ||||
| 17. Jornada | 08.12.2021 | FK Renova | - | GFK Tikvesh | 1:1 | ||||
| 18. Jornada | 14.12.2021 | FC Struga | - | FK Renova | 1:0 | ||||
| 21. Jornada | 28.02.2022 | FK Pelister | - | FK Renova | 1:1 |
Macedonia del Norte