| 11. Jornada | 20.03.2022 | CF América [Sub 18] | - | Deportivo Toluca [Sub 18] | 3:2 |  |
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| 12. Jornada | 03.04.2022 | Deportivo Toluca [Sub 18] | - | Puebla FC [Sub 18] | 0:1 | |
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| 13. Jornada | 09.04.2022 | Deportivo Toluca [Sub 18] | - | Deportivo Guadalajara [Sub 18] | 3:3 | ||||
| 15. Jornada | 19.04.2022 | Deportivo Toluca [Sub 18] | - | FC Juárez [Sub 18] | 4:0 |  |
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| 16. Jornada | 24.04.2022 | Deportivo Toluca [Sub 18] | - | Atlas Guadalajara [Sub 18] | 1:0 | ||||
| 14. Jornada | 27.04.2022 | UANL Tigres [Sub 18] | - | Deportivo Toluca [Sub 18] | 1:1 | ||||
| 17. Jornada | 01.05.2022 | Club León [Sub 18] | - | Deportivo Toluca [Sub 18] | 0:0 |
México