| 3. Jornada | 03.04.2022 | Inter Miami CF | - | Houston Dynamo | 1:3 | ||||
| 3. Jornada | 23.04.2022 | FC Dallas | - | Houston Dynamo | 2:1 | ||||
| 4. Jornada | 08.05.2022 | D.C. United | - | Houston Dynamo | 2:0 | ||||
| 4. Jornada | 15.05.2022 | Houston Dynamo | - | Nashville SC | 2:0 | ||||
| 4. Jornada | 19.05.2022 | Houston Dynamo | - | Seattle Sounders | 0:1 | ||||
| 6. Jornada | 04.07.2022 | Houston Dynamo | - | Charlotte FC | 1:2 | ||||
| 6. Jornada | 10.07.2022 | Houston Dynamo | - | FC Dallas | 2:2 | ||||
| 6. Jornada | 13.07.2022 | Austin FC | - | Houston Dynamo | 3:1 | ||||
| 6. Jornada | 24.07.2022 | Houston Dynamo | - | Minnesota United FC | 1:2 | ||||
| 7. Jornada | 06.08.2022 | Vancouver Whitecaps | - | Houston Dynamo | 2:1 | ||||
| 7. Jornada | 14.08.2022 | Houston Dynamo | - | CF Montréal | 2:3 | ||||
| 7. Jornada | 21.08.2022 | Colorado Rapids | - | Houston Dynamo | 1:1 | ||||
| 8. Jornada | 05.09.2022 | Seattle Sounders | - | Houston Dynamo | 2:1 | ||||
| 8. Jornada | 14.09.2022 | Houston Dynamo | - | New England Revolution | 3:1 | ||||
| 9. Jornada | 03.10.2022 | Nashville SC | - | Houston Dynamo | 1:2 |
Estados Unidos