| 2. Jornada | 02.03.2025 | Chicago Fire | - | D.C. United | 2:2 |  |
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| 3. Jornada | 09.03.2025 | FC Dallas | - | Chicago Fire | 1:3 | ||||
| 4. Jornada | 15.03.2025 | Toronto FC | - | Chicago Fire | 1:2 | ||||
| 5. Jornada | 23.03.2025 | Vancouver Whitecaps | - | Chicago Fire | 1:3 | ||||
| 6. Jornada | 30.03.2025 | Chicago Fire | - | CF Montréal | 1:1 | ||||
| 7. Jornada | 06.04.2025 | New York RB | - | Chicago Fire | 2:1 | ||||
| 9. Jornada | 20.04.2025 | Chicago Fire | - | FC Cincinnati | 2:3 | ||||
| 10. Jornada | 27.04.2025 | Nashville SC | - | Chicago Fire | 7:2 |
Estados Unidos