| 3. Jornada | 04.09.2021 | FC Wettswil-Bonstetten | - | FC St. Gallen II | 3:1 | ||||
| 11. Jornada | 07.11.2021 | FC St. Gallen II | - | FC Linth 04 | 3:1 | ||||
| 14. Jornada | 28.11.2021 | FC St. Gallen II | - | FC Gossau | 6:1 | ||||
| 15. Jornada | 05.03.2022 | FC Baden | - | FC St. Gallen II | 0:4 |  |
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| 16. Jornada | 13.03.2022 | FC St. Gallen II | - | FC Wettswil-Bonstetten | 1:0 | ||||
| 17. Jornada | 19.03.2022 | FC Paradiso | - | FC St. Gallen II | 2:1 | ||||
| 18. Jornada | 26.03.2022 | FC St. Gallen II | - | FC Freienbach | 2:2 | ||||
| 19. Jornada | 06.04.2022 | FC St. Gallen II | - | FC Lugano II | 7:2 | ||||
| 20. Jornada | 09.04.2022 | FC Winterthur II | - | FC St. Gallen II | 3:2 | ||||
| 21. Jornada | 23.04.2022 | FC St. Gallen II | - | FC Uzwil | 3:2 | ||||
| 22. Jornada | 30.04.2022 | FC Balzers | - | FC St. Gallen II | 1:2 | ||||
| 24. Jornada | 14.05.2022 | FC Linth 04 | - | FC St. Gallen II | 4:3 | ||||
| 26. Jornada | 28.05.2022 | FC Thalwil | - | FC St. Gallen II | 0:6 |  |
Suiza