| 5. Jornada | 05.09.2021 | Veraguas Club Deportivo | - | San Francisco FC | 1:0 | ||||
| 10. Jornada | 10.10.2021 | Sporting San Miguelito | - | San Francisco FC | 1:1 | ||||
| 11. Jornada | 16.10.2021 | San Francisco FC | - | Árabe Unido | 1:0 | ||||
| 12. Jornada | 23.10.2021 | San Francisco FC | - | Atlético Chiriquí | 1:0 |  |
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| 13. Jornada | 30.10.2021 | UD Universitario | - | San Francisco FC | 0:1 | ||||
| 14. Jornada | 06.11.2021 | San Francisco FC | - | Independiente de La Chorrera | 1:1 | ||||
| 15. Jornada | 13.11.2021 | Herrera FC | - | San Francisco FC | 2:1 | ||||
| 16. Jornada | 20.11.2021 | San Francisco FC | - | Veraguas Club Deportivo | 0:1 |
Panamá